Probiotics are gaining attention for their role in improving gut health, which is intricately connected to brain function. For individuals with autism, addressing gut-brain axis imbalances through probiotic supplementation can be a valuable approach. Here's a comprehensive guide on selecting the best probiotics for autism, what to consider in a supplement, and the role of prebiotics and fermented foods.

What to Look For in a Probiotic Supplement

When choosing a probiotic for someone with autism, consider these key factors:

Multistrain Formulation
A good probiotic should contain multiple strains of beneficial bacteria. Each strain has unique functions, and a combination can provide more comprehensive gut support. For autism, strains like Lactobacillus rhamnosus GG, Bifidobacterium longum, and Bifidobacterium infantis are particularly helpful.
Third-Party Testing
Third-party testing ensures the probiotic meets quality, potency, and purity standards. Look for certifications from reputable organizations like NSF, ConsumerLab, or USP.
Specific Strains for Autism
Research suggests that certain probiotic strains may reduce gastrointestinal (GI) symptoms and positively impact behavior in autism. Key strains include:
- Lactobacillus rhamnosus GG: Known for improving gut permeability and reducing GI symptoms.
- Bifidobacterium breve: May enhance cognitive and behavioral outcomes.
- Bifidobacterium longum: Supports gut health and reduces inflammation.
- Streptococcus thermophilus: Helps improve lactose digestion and reduce gas.
CFU Count
Probiotic efficacy depends on the number of colony-forming units (CFUs). For autism, products with at least 10 billion CFUs per dose are often recommended. Higher CFU counts can be beneficial for addressing severe gut imbalances.
Prebiotic Inclusion
Prebiotics are non-digestible fibers that feed beneficial bacteria. While some probiotic supplements include prebiotics, they are not always well-tolerated by individuals with small intestinal bacterial overgrowth (SIBO), which is common in autism. Choose a separate prebiotic if needed.

Prebiotics vs. Probiotics: Understanding the Difference

Probiotics: Live beneficial bacteria that populate the gut and support microbiome health.
Prebiotics: Non-digestible fibers like inulin and FOS (fructooligosaccharides) that nourish probiotics.

While probiotics introduce good bacteria, prebiotics ensure their survival and proliferation. However, introducing prebiotics to individuals with SIBO or sensitive digestive systems may lead to bloating and discomfort.

Fermented Foods as Natural Probiotics

In addition to supplements, fermented foods are a natural source of probiotics. These include:

Yogurt (dairy or non-dairy)
Kefir
Sauerkraut
Kimchi
Miso
Pickles (fermented, not vinegar-based)

These foods can be excellent additions to the diet but may not provide the same concentrated dose as supplements.

Forms of Probiotics

Probiotics come in various forms, making it easier to match them to an individual's needs:

Chewables: Ideal for children or those who struggle with swallowing capsules.
Capsules: Convenient and protect bacteria from stomach acid.
Powders: Great for mixing into food or beverages, especially for picky eaters.

Possible Side Effects

While probiotics are generally safe, some individuals with autism may experience side effects, especially during the initial stages of supplementation. Common side effects include:

Gas and bloating
Changes in stool consistency
Temporary worsening of GI symptoms

These are usually signs of gut flora adjustment. However, if symptoms persist or worsen significantly, it may indicate SIBO or another underlying issue. Working with a healthcare provider is crucial for proper guidance.

Top Probiotic Brands for Autism

Several high-quality probiotic brands have been trusted for their efficacy and safety. Here are some specific recommendations:

1. Klaire Labs Ther-Biotic Children’s Formula

Strains: Multiple strains, including Lactobacillus and Bifidobacterium.
Benefits: Tailored for sensitive individuals with no common allergens.
Form: Powder.

2. Microbiome Labs MegaSporeBiotic

Strains: Spore-based probiotics, including Bacillus indicus.
Benefits: Enhances gut integrity and reduces inflammation.
Form: Capsules.

3. Aspire Nutrition Bio-Heal

Strains: 12 strains, including Lactobacillus rhamnosus and Bifidobacterium breve.
Benefits: Supports GI health and behavior.
Form: Powder.

Probiotics can play a significant role in improving gut health and, subsequently, the overall well-being of individuals with autism. When selecting a probiotic, prioritize multistrain formulations, third-party testing, and strains known for their benefits in autism. Fermented foods can complement supplements, and prebiotics may enhance their effects when tolerated. However, it's essential to introduce probiotics gradually and monitor for side effects like bloating or changes in stool.

With trusted brands like Klaire Labs, Microbiome Labs, and Aspire Nutrition, you can make informed decisions to support your loved one’s gut and brain health. Always consult with a healthcare professional to tailor interventions to individual needs.

References

Bested, A. C., Logan, A. C., & Selhub, E. M. (2013). Intestinal microbiota, probiotics and mental health: From metchnikoff to modern advances: Part II – contemporary contextual research. Gut Pathogens, 5(1), 1-14. https://doi.org/10.1186/1757-4749-5-3

Finegold, S. M., Molitoris, D., Song, Y., Liu, C., Vaisanen, M. L., Bolte, E., ... & McTeague, M. (2002). Gastrointestinal microflora studies in late-onset autism. Clinical Infectious Diseases, 35(Suppl_1), S6-S16. https://doi.org/10.1086/341914

Hughes, H. K., Rose, D., & Ashwood, P. (2018). The gut microbiota and dysbiosis in autism spectrum disorders. Current Neurology and Neuroscience Reports, 18(11), 81. https://doi.org/10.1007/s11910-018-0887-2

Iovene, M. R., Bombace, F., Maresca, R., Sapone, A., Iardino, P., & Prisco, F. (2017). Intestinal permeability and its role in autism spectrum disorders. Frontiers in Pediatrics, 5, 69. https://doi.org/10.3389/fped.2017.00069

Liu, Y. W., Liong, M. T., Tsai, Y. C., Newell, E., & Shah, N. P. (2019). Beneficial effects of probiotics for functional gastrointestinal disorders. Nutrition Research Reviews, 32(1), 19-38. https://doi.org/10.1017/S0954422418000133

West, R., Roberts, E., Sichel, L. S., & Sichel, J. (2013). Improvements in gastrointestinal symptoms among children with autism spectrum disorder receiving the Delpro® probiotic and immunomodulator formulation. Clinical and Experimental Gastroenterology, 6, 127-137. https://doi.org/10.2147/CEG.S49406

The Best Probiotics for Autism: What to Look For and Top Recommendations